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From: Kuch
Date: 5/14/2002
Time: 1:54:56 PM
Remote Name: 66.88.192.59
Comments
Abstract TITLE: The expression of insulin-like growth factor-1 in follicular dermal papilla is associated with therapeutic efficacy of finasteride in male androgenetic alopecia AUTHORS (ALL): Shapiro, Jerry 1; Tang, Liren 1; Bernardo, Olga 1; Bolduc, Chantal 1; Madani, Shabnam 1; Lui, Harvey 1 INSTITUTIONS (ALL): 1. Dermatology, University of British Columbia, Vancouver, BC, CAN;
ABSTRACT BODY: Abstract Body: The purpose of this study is to identify and quantify changes in expression of specific molecular hair growth regulators in dermal papillae of men with androgenetic alopecia treated with finasteride. Scalp biopsies were collected from nine male patients from both balding and non-balding areas prior to and after 4 months of finasteride therapy. Dermal papillae were microdissected and total RNA extracted from equal number of dermal papillae of each biopsy. The expression of various cytokines including insulin-like growth factor-1 (IGF-1) was determined by RT-PCR. The signals were detected by autoradiography. Levels of IGF-1 mRNA as determined by RT-PCR were increased in 4/9 patients treated with finasteride for four months. Among the patients with increased IGF-1 expression, 3 showed significant clinical improvement and another patient remained the same after 12 months of treatment. In contrast, 3 patients with decreased IGF-1 showed worsening clinically after 12 months. The other two patients without noticeable change in IGF-1 showed either slight improvement or no change. In a small uncontrolled study of nine male patients with androgenetic alopecia, an increase of expression of scalp IGF-1 mRNA levels was associated with patient response to finasteride.
Kuch
From: France
Date: 17 Apr 2007
Time: 10:50:38
Remote Name: 61.254.15.45
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