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From: Kuch
Date: 5/14/2002
Time: 1:45:24 PM
Remote Name: 66.88.192.59
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Abstract TITLE: Trophic effects of estrogens and androgens on human hair bulb melanocytes in hair follicle organ culture AUTHORS (ALL): Thornton, Julie 1; Tobin, Desmond J1 INSTITUTIONS (ALL): 1. Department of Biomedical Sciences, University of Bradford, Bradford, West Yorkshire, UK;
ABSTRACT BODY: Abstract Body: Several studies have suggested a role for estrogens and androgens in regulating mammalian pigmentation. While some areas become hyperpigmented after puberty when plasma androgens rise, some become hyperpigmented during pregnancy when estrogen levels rise. Furthermore, these steroid hormones may also be important in regulating hair and coat color. In order to establish a role for estrogens and androgens in human hair follicle melanocyte biology, we examined the effects of these hormones in an organ culture system. Hair follicles isolated from occipital male scalp were graded morphologically for quality and growth cycle stage. Intact anagen VI follicles were grown in glucose supplemented William's E serum-free medium containing vehicle (0.0001% ethanol), or either 10 nM testosterone, 10 nM 5-dihydrotesterone, 10 nM 17-estradiol, or combinations of 17-estradiol with either testosterone or 5-dihydrotesterone. After 4 days hair follicles were assessed by high-resolution light microscopy and transmission electron microscopy. Most pigmented hair bulb melanocytes were lost from control hair follicles (n=4), while remaining melanocytes exhibited evidence of apoptosis. By contrast, hair follicles grown in estradiol contained many hair bulb and outer root sheath melanocytes. The former also exhibited their characteristic dendritic and pigmented phenotypes and remarkably were occasionally seen to proliferate. Hair follicles treated with 5-dihydrotesterone however, contained several pigmentary abnormalities including cell apoptosis, pigment clumping, and clustering of degenerating pigment cells transferred to the pre-cortex. Similar, but milder, effects were seen with testosterone. Estradiol combined with either androgen did not completely reverse these melanocyte defects. For the first time, this study demonstrates that both estrogens and androgens have a direct role on hair follicle melanocytes. Although, both steroid hormones positively influence hair follicle melanocyte homeostasis, estrogens markedly increase cell survival.
Kuch
From: <Default>
Date: 17 Apr 2007
Time: 00:19:25
Remote Name: 84.108.220.3
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