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From: Kuch
Date: 5/14/2002
Time: 1:44:46 PM
Remote Name: 66.88.192.59
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Abstract TITLE: Dermal papilla specific genes identified by microarray analysis AUTHORS (ALL): O'Shaughnessy, Ryan 1; Jahoda, Colin 2; Christiano, Angela 1 INSTITUTIONS (ALL): 1. Dermatology and Genetics and Development, Columbia University, New York, NY, USA; 2. Biological Sciences, Durham University, Durham, , UK;
ABSTRACT BODY: Abstract Body: At the base of a cycling vibrissa (whisker) follicle there are two distinct mesenchymal populations, the dermal papilla (DP), which is thought to provide the signals required to produce hair growth, and the dermal sheath cells (DS), a closely biologically related, yet distinct tissue whose function is largely unknown. In rodents, the dermal papilla retains the ability to induce new hair follicle production, while the dermal sheath does not have this inductive capability. We believe that the differences in gene expression between these two specialized mesenchymal tissues will shed light on their functions in morphogenesis and the continued cycling of the hair follicle. We compared microdissected intact DP and DS from the vibrissae of male brown Norway rats using Affymetrix genechips of over 8000 genes. Of the 8000 genes on the chips, only 800 were present in both tissues. Of these 800, only 30 were differentially expressed. Further validations steps by RT-PCR revealed that of these 30 genes only 8 were specifically expressed in the DP and not in the rest of the hair follicle. Of interest among these 8 genes were 4 secreted genes, 3 of which have been shown to inhibit extracellular proteases – including the known dermal papilla marker Nexin 1. Two of the inhibitor of DNA binding (ID) family of genes were also identified. We show that the secreted genes show variation of expression during the hair cycle of the vibrissa, and that a novel gene, a homologue of the gene mutated in bone dysplasia sclerostosis is preferentially expressed in DP. We conclude that there are indeed genes specifically expressed by the DP and that microarray analysis of freshly dissected tissue is a viable approach to detect such genes.
Kuch
From: <Default>
Date: 17 Apr 2007
Time: 00:15:03
Remote Name: 84.108.220.79
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