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From: Kuch
Date: 5/14/2002
Time: 1:44:08 PM
Remote Name: 66.88.192.59
Comments
Abstract TITLE: Topical application of a PKC inhibitor reduces length and thickness of guinea pig and mouse hair in vivo AUTHORS (ALL): Park, H.Y. 1; Gonzalez, S. 2; Lee, J. 1; Middelkamp-Hup, M.A. 2; Kaposi, S. 1; Peterson, S. 1; Gilchrest, B.A. 1 INSTITUTIONS (ALL): 1. Dermatology, Boston University School of Medicine, Boston, MA, USA; 2. Dermatology, Harvard Medical School, Boston, MA, USA;
ABSTRACT BODY: Abstract Body: Protein Kinase C (PKC) has been suggested to play an important role during differentiation of keratinocytes. To determine whether modulation of PKC activity would alter development of hair, the differentiated product of keratinocytes in hair follicles, a selective PKC inhibitor, bisindolylmaleimide (Bis), was topically applied to rodent skin. Backs of 9-week old mice were first depilated to initiate a synchronized anagen hair cycle. Vehicle alone or 100 mM Bis was topically applied daily for 7-12 days. After the last application, at least 15 hairs were plucked from the Bis-treated and vehicle-treated areas, and the length and the diameter of hair shafts were determined using a dissecting microscope. Hair length in Bis-treated areas was significantly shorter than in vehicle-treated areas (2.6±1.4 vs. 6.2±2.0 mm, p<0.00001). Similarly, hair diameter from the Bis-treated areas was less than in vehicle-treated area (0.026±0.02 vs 0.038±0.02 mm, p<0.03). In a second model, the guinea pig, paired sites on the back were depilated and 200 uM Bis or vehicle alone {25% DMSO/75% propylene glycol (v/v)} was applied twice a day for 14 working days over period of 18 days. At the end of the treatment, at least 30 hairs from each site were plucked and measured. Bis treatment again shortened hair length compared to vehicle treatment (2.05±0.7 vs 4.69±2.0 mm, p<0.0001); and the diameter of Bis-treated hair was similarly less than that of vehicle treated hair (0.039±0.027 vs 0.053±0.014 mm, p<0.013). Skin biopsies revealed no difference in epidermal morphology in Bis-treated vs. control sites and the hair follicles were not dystrophic. Taken together, these results suggest that PKC may positively regulate hair growth and thickness and that topically applied PKC inhibitors may be useful in decreasing unwanted facial or body hair.
Kuch
From: France
Date: 16 Apr 2007
Time: 21:27:17
Remote Name: 82.127.6.89
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